Updates on Female Sexual Health


HSDD (hypoactive sexual desire disorder) is a low sex drive which causes personal or inter-personal distress which is not due to any medical, psychiatric or problem within the relation.


Addyi (Flibanserin)

Vyleesi (Bremelanotide)

What we want..

FDA Approval

August, 2015

June, 2019

not soon enough






Premenopausal women

Premenopausal women

Postmenopausal women


Pill taken daily

(doesn’t enhance sexual performance)

Injection under skin of abdomen or thigh at least 45 minutes prior to sexual activity 

(doesn’t enhance sexual performance)

A pill or cream that can  be applied to skin 30- 45 minutes before sexual activity


$25-$99/ permonth

Not known

Covered by insurance


No alcohol- at least 2 hr prior taking Addyi; 

No alcohol until AM if taking at bedtime

No more than 1 injection within 24 hr; no more than 8 doses per month; 

Not to be used with uncontrolled Hypertension, cardiovascular disease or at high risk of cardiovascular disease

Safe, Well studied. No contraindications to alcohol or co-morbidities such as hypertension,cardiovascular disease

Pharmaceutical company

Sprout Pharmaceuticals

AMAG Pharmaceuticals

Yet to be named


Serotonin 1A & 2A receptor antagonist

Activates melanocortin receptors

If it’s all in her head, able to explain how it works

Mechanism of action




Discontinue use if..

No improvement in 8 weeks

No improvement in 8 weeks

No improvement in 8 weeks

Common reactions 

Dizziness, sleepiness, nausea

Nausea & vomiting, flushing, reaction at injection site

May cause darkening of skin, gums

“After glow”, relaxation, sleepiness


Sharan Abdul-Rahman, MD

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