Review of a recent study published in the New England Journal of Medicine
FEMALE SEXUAL DYSFUNCTION includes:
HSDD (hypoactive sexual desire disorder) is a low sex drive which causes personal or inter-personal distress which is not due to any medical, psychiatric or problem within the relation.
|
MEDICATIONS: |
Addyi (Flibanserin) |
Vyleesi (Bremelanotide) |
What we want.. |
|
FDA Approval |
August, 2015 |
June, 2019 |
not soon enough |
|
Indication |
HSDD |
HSDD |
HSDD |
|
Audience |
Premenopausal women |
Premenopausal women |
Postmenopausal women |
|
Form |
Pill taken daily (doesn’t enhance sexual performance) |
Injection under skin of abdomen or thigh at least 45 minutes prior to sexual activity (doesn’t enhance sexual performance) |
A pill or cream that can be applied to skin 30- 45 minutes before sexual activity |
|
Cost |
$25-$99/ permonth |
Not known |
Covered by insurance |
|
Warning |
No alcohol- at least 2 hr prior taking Addyi; No alcohol until AM if taking at bedtime |
No more than 1 injection within 24 hr; no more than 8 doses per month; Not to be used with uncontrolled Hypertension, cardiovascular disease or at high risk of cardiovascular disease |
Safe, Well studied. No contraindications to alcohol or co-morbidities such as hypertension,cardiovascular disease |
|
Pharmaceutical company |
Sprout Pharmaceuticals |
AMAG Pharmaceuticals |
Yet to be named |
|
Drug |
Serotonin 1A & 2A receptor antagonist |
Activates melanocortin receptors |
If it’s all in her head, able to explain how it works |
|
Mechanism of action |
Unknown |
Unknown |
Known |
|
Discontinue use if.. |
No improvement in 8 weeks |
No improvement in 8 weeks |
No improvement in 8 weeks |
|
Common reactions |
Dizziness, sleepiness, nausea |
Nausea & vomiting, flushing, reaction at injection site May cause darkening of skin, gums |
“After glow”, relaxation, sleepiness |
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