FEMALE SEXUAL DYSFUNCTION includes:
- Pain with sex
- Inability to orgasm
- Low sex drive
HSDD (hypoactive sexual desire disorder) is a low sex drive which causes personal or inter-personal distress which is not due to any medical, psychiatric or problem within the relation.
MEDICATIONS:
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Addyi (Flibanserin)
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Vyleesi (Bremelanotide)
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What we want..
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FDA Approval
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August, 2015
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June, 2019
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not soon enough
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Indication
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HSDD
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HSDD
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HSDD
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Audience
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Premenopausal women
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Premenopausal women
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Postmenopausal women
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Form
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Pill taken daily
(doesn’t enhance sexual performance)
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Injection under skin of abdomen or thigh at least 45 minutes prior to sexual activity
(doesn’t enhance sexual performance)
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A pill or cream that can be applied to skin 30- 45 minutes before sexual activity
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Cost
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$25-$99/ permonth
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Not known
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Covered by insurance
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Warning
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No alcohol- at least 2 hr prior taking Addyi;
No alcohol until AM if taking at bedtime
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No more than 1 injection within 24 hr; no more than 8 doses per month;
Not to be used with uncontrolled Hypertension, cardiovascular disease or at high risk of cardiovascular disease
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Safe, Well studied. No contraindications to alcohol or co-morbidities such as hypertension,cardiovascular disease
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Pharmaceutical company
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Sprout Pharmaceuticals
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AMAG Pharmaceuticals
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Yet to be named
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Drug
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Serotonin 1A & 2A receptor antagonist
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Activates melanocortin receptors
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If it’s all in her head, able to explain how it works
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Mechanism of action
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Unknown
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Unknown
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Known
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Discontinue use if..
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No improvement in 8 weeks
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No improvement in 8 weeks
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No improvement in 8 weeks
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Common reactions
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Dizziness, sleepiness, nausea
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Nausea & vomiting, flushing, reaction at injection site
May cause darkening of skin, gums
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“After glow”, relaxation, sleepiness
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Author
Sharan Abdul-Rahman, MD